Amino acid–insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells

The mTOR pathway is a critical determinant of cell persistence and growth wherein mTOR complex 1 (mTORC1) mediates a balance between growth factor stimuli and nutrient availability. Amino acids or glucose facilitates mTORC1 activation by inducing RagA GTPase recruitment of mTORC1 to the lysosomal ou...

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Publicado en:J Clin Invest
Autores principales: Kalaitzidis, Demetrios, Lee, Dongjun, Efeyan, Alejo, Kfoury, Youmna, Nayyar, Naema, Sykes, David B., Mercier, Francois E., Papazian, Ani, Baryawno, Ninib, Victora, Gabriel D., Neuberg, Donna, Sabatini, David M., Scadden, David T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373863/
https://ncbi.nlm.nih.gov/pubmed/28319048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89452
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