Germinal center selection and affinity maturation require dynamic regulation of mTORC1 kinase

During antibody affinity maturation, germinal center (GC) B cells cycle between affinity-driven selection in the light zone (LZ) and proliferation and somatic hypermutation in the dark zone (DZ). Although selection of GC B cells is triggered by antigen-dependent signals delivered in the LZ, DZ proli...

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Publicat a:Immunity
Autors principals: Ersching, Jonatan, Efeyan, Alejo, Mesin, Luka, Jacobsen, Johanne T., Pasqual, Giulia, Grabiner, Brian C., Dominguez-Sola, David, Sabatini, David M., Victora, Gabriel D.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526448/
https://ncbi.nlm.nih.gov/pubmed/28636954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.06.005
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