Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival

The mTOR Complex 1 (mTORC1) pathway regulates organismal growth in response to many environmental cues, including nutrients and growth factors(1). Cell-based studies showed that mTORC1 senses amino acids through the Rag family of GTPases (2,3), but their importance in mammalian physiology is unknown...

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Main Authors: Efeyan, Alejo, Zoncu, Roberto, Chang, Steven, Gumper, Iwona, Snitkin, Harriet, Wolfson, Rachel L., Kirak, Oktay, Sabatini, David D., Sabatini, David M.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000705/
https://ncbi.nlm.nih.gov/pubmed/23263183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11745
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