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Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival
The mTOR Complex 1 (mTORC1) pathway regulates organismal growth in response to many environmental cues, including nutrients and growth factors(1). Cell-based studies showed that mTORC1 senses amino acids through the Rag family of GTPases (2,3), but their importance in mammalian physiology is unknown...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4000705/ https://ncbi.nlm.nih.gov/pubmed/23263183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11745 |
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