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Amino acids and mTORC1: from lysosomes to disease

The mechanistic target of rapamycin (mTOR) kinase controls growth and metabolism, and its deregulation underlies the pathogenesis of many diseases, including cancer, neurodegeneration, and diabetes. mTOR complex 1 (mTORC1) integrates signals arising from nutrients, energy, and growth factors, but ho...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Efeyan, Alejo, Zoncu, Roberto, Sabatini, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432651/
https://ncbi.nlm.nih.gov/pubmed/22749019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2012.05.007
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