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Amino acids and mTORC1: from lysosomes to disease

The mechanistic target of rapamycin (mTOR) kinase controls growth and metabolism, and its deregulation underlies the pathogenesis of many diseases, including cancer, neurodegeneration, and diabetes. mTOR complex 1 (mTORC1) integrates signals arising from nutrients, energy, and growth factors, but ho...

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Hlavní autoři: Efeyan, Alejo, Zoncu, Roberto, Sabatini, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432651/
https://ncbi.nlm.nih.gov/pubmed/22749019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2012.05.007
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