Wird geladen...
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the Vacuolar H(+)-ATPase
The mTOR Complex 1 (mTORC1) protein kinase is a master growth regulator that is stimulated by amino acids. Amino acids activate the Rag guanosine triphosphatases (GTPases), which promote the translocation of mTORC1 to the lysosomal surface, the site of mTORC1 activation. We found that the vacuolar H...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3211112/ https://ncbi.nlm.nih.gov/pubmed/22053050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1207056 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|