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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the Vacuolar H(+)-ATPase
The mTOR Complex 1 (mTORC1) protein kinase is a master growth regulator that is stimulated by amino acids. Amino acids activate the Rag guanosine triphosphatases (GTPases), which promote the translocation of mTORC1 to the lysosomal surface, the site of mTORC1 activation. We found that the vacuolar H...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3211112/ https://ncbi.nlm.nih.gov/pubmed/22053050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1207056 |
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