Architecture of human Rag GTPase heterodimers and their complex with mTORC1

The Rag GTPases recruit the master kinase mTORC1 to lysosomes to regulate cell growth and proliferation in response to amino acid availability. The nucleotide state of Rag heterodimers is critical for their association with mTORC1. Our cryo-EM structure of RagA/RagC in complex with mTORC1 shows the...

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Publicado en:Science
Autores principales: Anandapadamanaban, Madhanagopal, Masson, Glenn R., Perisic, Olga, Berndt, Alex, Kaufman, Jonathan, Johnson, Chris M., Santhanam, Balaji, Rogala, Kacper B., Sabatini, David M., Williams, Roger L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795536/
https://ncbi.nlm.nih.gov/pubmed/31601764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax3939
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