Glutamine and asparagine activate mTORC1 independently of Rag GTPases

Nutrient sensing by cells is crucial, and when this sensing mechanism is disturbed, human disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Leucine, arginine, and methionine signal to mTORC1 through the well-characterized Rag GTPase sign...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Meng, Delong, Yang, Qianmei, Wang, Huanyu, Melick, Chase H., Navlani, Rishika, Frank, Anderson R., Jewell, Jenna L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Editors' Picks
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062167/
https://ncbi.nlm.nih.gov/pubmed/32019866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.011578
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