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Glutamine and asparagine activate mTORC1 independently of Rag GTPases
Nutrient sensing by cells is crucial, and when this sensing mechanism is disturbed, human disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Leucine, arginine, and methionine signal to mTORC1 through the well-characterized Rag GTPase sign...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7062167/ https://ncbi.nlm.nih.gov/pubmed/32019866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.011578 |
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