Metformin, Independent of AMPK, Inhibits mTORC1 In a Rag GTPase-Dependent Manner

Dysfunctional mTORC1 signaling is associated with a number of human pathologies owing to its central role in controlling cell growth, proliferation, and metabolism. Regulation of mTORC1 is achieved by the integration of multiple inputs, including those of mitogens, nutrients, and energy. It is thoug...

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Bibliografiske detaljer
Main Authors:	Kalender, Adem, Selvaraj, Anand, Kim, So Young, Gulati, Pawan, lé, Sophie Br, Viollet, Benoit, Kemp, Bruce, Bardeesy, Nabeel, Dennis, Patrick, Schlager, John J., Marette, André, Kozma, Sara C., Thomas, George
Format:	Artigo
Sprog:	Inglês
Udgivet:	2010
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3081779/ https://ncbi.nlm.nih.gov/pubmed/20444419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.03.014
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Metformin, Independent of AMPK, Inhibits mTORC1 In a Rag GTPase-Dependent Manner

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