Metformin, Independent of AMPK, Inhibits mTORC1 In a Rag GTPase-Dependent Manner

Dysfunctional mTORC1 signaling is associated with a number of human pathologies owing to its central role in controlling cell growth, proliferation, and metabolism. Regulation of mTORC1 is achieved by the integration of multiple inputs, including those of mitogens, nutrients, and energy. It is thoug...

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Detalhes bibliográficos
Main Authors: Kalender, Adem, Selvaraj, Anand, Kim, So Young, Gulati, Pawan, lé, Sophie Br, Viollet, Benoit, Kemp, Bruce, Bardeesy, Nabeel, Dennis, Patrick, Schlager, John J., Marette, André, Kozma, Sara C., Thomas, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081779/
https://ncbi.nlm.nih.gov/pubmed/20444419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.03.014
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