Metformin, Independent of AMPK, Inhibits mTORC1 In a Rag GTPase-Dependent Manner

Dysfunctional mTORC1 signaling is associated with a number of human pathologies owing to its central role in controlling cell growth, proliferation, and metabolism. Regulation of mTORC1 is achieved by the integration of multiple inputs, including those of mitogens, nutrients, and energy. It is thoug...

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Hlavní autoři: Kalender, Adem, Selvaraj, Anand, Kim, So Young, Gulati, Pawan, lé, Sophie Br, Viollet, Benoit, Kemp, Bruce, Bardeesy, Nabeel, Dennis, Patrick, Schlager, John J., Marette, André, Kozma, Sara C., Thomas, George
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081779/
https://ncbi.nlm.nih.gov/pubmed/20444419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.03.014
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