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Intersubunit crosstalk in the Rag GTPase heterodimer enables mTORC1 to respond rapidly to amino acid availability

mTORC1 is a central growth regulator that senses amino acids through a pathway that converges on the Rag GTPases, an obligate heterodimer of two related GTPases. Despite their central role in amino acid sensing, it is unknown why the Rag GTPases are heterodimeric and if their subunits communicate wi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Shen, Kuang, Choe, Abigail, Sabatini, David M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674802/
https://ncbi.nlm.nih.gov/pubmed/29056322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.09.026
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