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An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids
Cellular growth and proliferation are primarily dictated by the mechanistic target of rapamycin complex 1 (mTORC1), which balances nutrient availability against the cell’s anabolic needs. Central to the activity of mTORC1 is the RagA–RagC GTPase heterodimer, which under favorable conditions recruits...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8254048/ https://ncbi.nlm.nih.gov/pubmed/34116056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100861 |
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