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Intersubunit crosstalk in the Rag GTPase heterodimer enables mTORC1 to respond rapidly to amino acid availability
mTORC1 is a central growth regulator that senses amino acids through a pathway that converges on the Rag GTPases, an obligate heterodimer of two related GTPases. Despite their central role in amino acid sensing, it is unknown why the Rag GTPases are heterodimeric and if their subunits communicate wi...
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| Publicat a: | Mol Cell |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5674802/ https://ncbi.nlm.nih.gov/pubmed/29056322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.09.026 |
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