Amino acid–insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells

The mTOR pathway is a critical determinant of cell persistence and growth wherein mTOR complex 1 (mTORC1) mediates a balance between growth factor stimuli and nutrient availability. Amino acids or glucose facilitates mTORC1 activation by inducing RagA GTPase recruitment of mTORC1 to the lysosomal ou...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Kalaitzidis, Demetrios, Lee, Dongjun, Efeyan, Alejo, Kfoury, Youmna, Nayyar, Naema, Sykes, David B., Mercier, Francois E., Papazian, Ani, Baryawno, Ninib, Victora, Gabriel D., Neuberg, Donna, Sabatini, David M., Scadden, David T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373863/
https://ncbi.nlm.nih.gov/pubmed/28319048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89452
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares