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Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy
Regulation of STAT3 activation is critical for normal and malignant hematopoietic cell proliferation. Here, we have reported that the endogenous transmembrane protein upstream-of-mTORC2 (UT2) negatively regulates activation of STAT3. Specifically, we determined that UT2 interacts directly with GP130...
Shranjeno v:
| izdano v: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4811118/ https://ncbi.nlm.nih.gov/pubmed/26927669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84620 |
| Oznake: |
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