Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy

Regulation of STAT3 activation is critical for normal and malignant hematopoietic cell proliferation. Here, we have reported that the endogenous transmembrane protein upstream-of-mTORC2 (UT2) negatively regulates activation of STAT3. Specifically, we determined that UT2 interacts directly with GP130...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Lee, Dongjun, Wang, Ying-Hua, Kalaitzidis, Demetrios, Ramachandran, Janani, Eda, Homare, Sykes, David B., Raje, Noopur, Scadden, David T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811118/
https://ncbi.nlm.nih.gov/pubmed/26927669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84620
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