Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy

Regulation of STAT3 activation is critical for normal and malignant hematopoietic cell proliferation. Here, we have reported that the endogenous transmembrane protein upstream-of-mTORC2 (UT2) negatively regulates activation of STAT3. Specifically, we determined that UT2 interacts directly with GP130...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Lee, Dongjun, Wang, Ying-Hua, Kalaitzidis, Demetrios, Ramachandran, Janani, Eda, Homare, Sykes, David B., Raje, Noopur, Scadden, David T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811118/
https://ncbi.nlm.nih.gov/pubmed/26927669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84620
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