Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy

Regulation of STAT3 activation is critical for normal and malignant hematopoietic cell proliferation. Here, we have reported that the endogenous transmembrane protein upstream-of-mTORC2 (UT2) negatively regulates activation of STAT3. Specifically, we determined that UT2 interacts directly with GP130...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Lee, Dongjun, Wang, Ying-Hua, Kalaitzidis, Demetrios, Ramachandran, Janani, Eda, Homare, Sykes, David B., Raje, Noopur, Scadden, David T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811118/
https://ncbi.nlm.nih.gov/pubmed/26927669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84620
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