Integrity of mTORC2 is dependent on the rictor Gly-934 site

Growth factor signaling coupled to activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway plays a crucial role in the regulation of cell proliferation and survival. The key regulatory kinase of Akt has been identified as mammalian target of rapamycin complex 2 (mTORC2), which function...

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Autors principals: Aimbetov, R, Chen, C-H, Bulgakova, O, Abetov, D, Bissenbaev, AK, Bersimbaev, RI, Sarbassov, DD
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305845/
https://ncbi.nlm.nih.gov/pubmed/21909137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.404
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