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Endoplasmic reticulum is a main localization site of mTORC2
The Akt kinase is a critical effector in growth factor signaling. Activation of Akt driven by the growth factor dependent PI3K (phosphatidylinositol-3-OH kinase) is coupled to the plasma membrane translocation and phosphorylation of Akt on two sites by PDK1 (phosphoinositide-dependent protein kinase...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3225125/ https://ncbi.nlm.nih.gov/pubmed/21867682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.08.034 |
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