Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

The mammalian target of rapamycin (mTOR) regulates cell growth and survival by integrating nutrient and hormonal signals. These signaling functions are distributed between at least two distinct mTOR protein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to the selective inhibitor rapamycin and ac...

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Hlavní autoři: Feldman, Morris E, Apsel, Beth, Uotila, Aino, Loewith, Robbie, Knight, Zachary A, Ruggero, Davide, Shokat, Kevan M
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637922/
https://ncbi.nlm.nih.gov/pubmed/19209957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000038
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