Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Lignende værker

• The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling
  af: Delgoffe, Greg M., et al.
  Udgivet: (2011)
• Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR
  af: Wang, Lifu, et al.
  Udgivet: (2009)
• mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
  af: Soliman, Ghada A., et al.
  Udgivet: (2010)
• Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
  af: Barlow, A. D., et al.
  Udgivet: (2012)
• The “other” mTOR complex: new insights into mTORC2 immunobiology and their implications
  af: Dai, Helong, et al.
  Udgivet: (2019)