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The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling
mTOR has emerged as an important regulator of T helper cell differentiation. Here we demonstrate that T(H)1 and T(H)17 differentiation is selectively regulated by Rheb-dependent mTOR complex 1 (mTORC1) signaling. Rheb-deficient T cells fail to generate T(H)1 and T(H)17 responses in vitro and in vivo...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077821/ https://ncbi.nlm.nih.gov/pubmed/21358638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2005 |
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