The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling

mTOR has emerged as an important regulator of T helper cell differentiation. Here we demonstrate that T(H)1 and T(H)17 differentiation is selectively regulated by Rheb-dependent mTOR complex 1 (mTORC1) signaling. Rheb-deficient T cells fail to generate T(H)1 and T(H)17 responses in vitro and in vivo...

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Main Authors: Delgoffe, Greg M., Pollizzi, Kristen N., Waickman, Adam T., Heikamp, Emily, Meyers, David J., Horton, Maureen R., Xiao, Bo, Worley, Paul F., Powell, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077821/
https://ncbi.nlm.nih.gov/pubmed/21358638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2005
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