mTOR: taking cues from the immune microenvironment

Por Delgoffe, Greg M, Powell, Jonathan D
Publicado em 2009

The mammalian Target of Rapamycin (mTOR) provides a critical link between T cell differentiation, function and metabolism

Por Powell, Jonathan D., Delgoffe, Greg M.
Publicado em 2010

Exploring Functional In Vivo Consequences of the Selective Genetic Ablation of mTOR Signaling in T Helper Lymphocytes

Por Delgoffe, Greg M., Powell, Jonathan D.
Publicado em 2012

Sugar, fat, and protein: new insights into what T cells crave

Por Delgoffe, Greg M., Powell, Jonathan D.
Publicado no Curr Opin Immunol (2015)

Feeding an army: the metabolism of T cells in activation, anergy, and exhaustion

Por Delgoffe, Greg M., Powell, Jonathan D.
Publicado no Mol Immunol (2015)

Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity

Por Scharping, Nicole E., Delgoffe, Greg M.
Publicado no Vaccines (Basel) (2016)

STAT heterodimers in immunity: A mixed message or a unique signal?

Por Delgoffe, Greg M., Vignali, Dario A.A.
Publicado em 2013

Interpreting mixed signals: the cell’s cytokine conundrum

Por Delgoffe, Greg M., Murray, Peter J., Vignali, Dario AA
Publicado em 2011

Identity Crisis: It’s Not Just Foxp3 Anymore

Por Delgoffe, Greg M., Bettini, Matthew L., Vignali, Dario A. A.
Publicado em 2012

Metabolic insufficiency underlies intratumoral cytotoxic T cell dysfunction

Por Gupta, Tushar, Scharping, Nicole E, Moreci, Rebecca S, Delgoffe, Greg M
Publicado no J Immunother Cancer (2015)

Tumor-derived alpha-fetoprotein (tAFP) causes immune and metabolic dysfunction in monocyte-derived dendritic cells

Por Santos, Patricia M, Pardee, Angela, Delgoffe, Greg M, Butterfield, Lisa H
Publicado no J Immunother Cancer (2015)

Elucidating the role of Neuropilin-1 in intra-tumoral regulatory T cell stability

Por Overacre, Abigail E, Chikina, Maria, Delgoffe, Greg M, Vignali, Dario AA
Publicado no J Immunother Cancer (2015)

Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation

Por Delgoffe, Greg M., Kole, Thomas P., Cotter, Robert J., Powell, Jonathan D.
Publicado em 2009

Anergic T Cells Are Metabolically Anergic

Por Zheng, Yan, Delgoffe, Greg M., Meyer, Christian F., Chan, Waipan, Powell, Jonathan D.
Publicado em 2009

Murine mast cells rapidly modulate metabolic pathways essential for distinct effector functions()

Por Phong, Binh, Avery, Lyndsay, Menk, Ashley V., Delgoffe, Greg M., Kane, Lawrence P.
Publicado no J Immunol (2016)

Regulatory T Cells Do Not Mediate Suppression Via Programmed Cell Death Pathways

Por Szymczak-Workman, Andrea L., Delgoffe, Greg M., Green, Douglas R., Vignali, Dario A.A.
Publicado em 2011

Efficacy of PD-1 blockade is potentiated by metformin-induced reduction of tumor hypoxia

Por Scharping, Nicole E., Menk, Ashley V., Whetstone, Ryan D., Zeng, Xue, Delgoffe, Greg M.
Publicado no Cancer Immunol Res (2016)

Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) T(reg) cells are a source of tumour-associated T(reg) cells

Por Downs-Canner, Stephanie, Berkey, Sara, Delgoffe, Greg M., Edwards, Robert P., Curiel, Tyler, Odunsi, Kunle, Bartlett, David L., Obermajer, Nataša
Publicado no Nat Commun (2017)

mTORC1 and mTORC2 selectively regulate CD8(+) T cell differentiation

Por Pollizzi, Kristen N., Patel, Chirag H., Sun, Im-Hong, Oh, Min-Hee, Waickman, Adam T., Wen, Jiayu, Delgoffe, Greg M., Powell, Jonathan D.
Publicado no J Clin Invest (2015)

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Por Scharping, Nicole E., Menk, Ashley V., Moreci, Rebecca S., Whetstone, Ryan D., Dadey, Rebekah E., Watkins, Simon C., Ferris, Robert L., Delgoffe, Greg M.
Publicado no Immunity (2016)