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Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation

The mammalian target of rapamycin (mTOR) is an evolutionarily conserved kinase which plays a role in integrating environmental cues. mTOR signals via two complexes: TORC1, which contains the Regulatory Associated Protein of TOR (raptor), and TORC2, which contains the Rapamycin-Insensitive Companion...

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Detalhes bibliográficos
Main Authors: Delgoffe, Greg M., Kole, Thomas P., Cotter, Robert J., Powell, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768125/
https://ncbi.nlm.nih.gov/pubmed/19586661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.05.185
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