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Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation

The mammalian target of rapamycin (mTOR) is an evolutionarily conserved kinase which plays a role in integrating environmental cues. mTOR signals via two complexes: TORC1, which contains the Regulatory Associated Protein of TOR (raptor), and TORC2, which contains the Rapamycin-Insensitive Companion...

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Main Authors: Delgoffe, Greg M., Kole, Thomas P., Cotter, Robert J., Powell, Jonathan D.
格式: Artigo
語言:Inglês
出版: 2009
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768125/
https://ncbi.nlm.nih.gov/pubmed/19586661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.05.185
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