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mTORC1 and mTORC2 in cancer and the tumor microenvironment
The mammalian target of rapamycin (mTOR) is a crucial signaling node that integrates environmental cues to regulate cell survival, proliferation, and metabolism, and is often deregulated in human cancer. mTOR kinase acts in two functionally distinct complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2),...
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| Udgivet i: | Oncogene |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5393956/ https://ncbi.nlm.nih.gov/pubmed/27748764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.363 |
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