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mTORC1 and mTORC2 in cancer and the tumor microenvironment

The mammalian target of rapamycin (mTOR) is a crucial signaling node that integrates environmental cues to regulate cell survival, proliferation, and metabolism, and is often deregulated in human cancer. mTOR kinase acts in two functionally distinct complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2),...

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Pubblicato in:Oncogene
Autori principali: Kim, Laura C., Cook, Rebecca S., Chen, Jin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393956/
https://ncbi.nlm.nih.gov/pubmed/27748764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.363
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