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Localization of mTORC2 activity inside cells

Activation of protein kinase Akt via its direct phosphorylation by mammalian target of rapamycin (mTOR) complex 2 (mTORC2) couples extracellular growth and survival cues with pathways controlling cell growth and proliferation, yet how growth factors target the activity of mTORC2 toward Akt is unknow...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Ebner, Michael, Sinkovics, Benjamin, Szczygieł, Magdalena, Ribeiro, Daniela Wolfschoon, Yudushkin, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294791/
https://ncbi.nlm.nih.gov/pubmed/28143890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201610060
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