mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition

The current concept is that Tsc-deficient cells are sensitized to apoptosis due to the inhibition of Akt activity by the negative feedback mechanism induced by the hyperactive mTORC1. Unexpectedly, however, we found that Tsc1/2-deficient cells exhibit increased resistance to serum deprivation-induce...

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Bibliographic Details
Main Authors: Bhaskar, Prashanth T., Nogueira, Veronique, Patra, Krushna C., Jeon, Sang-Min, Park, Youngkyu, Robey, R. Brooks, Hay, Nissim
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738274/
https://ncbi.nlm.nih.gov/pubmed/19620286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01946-08
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