טוען...
mTORC1 promotes survival through translational control of Mcl-1
Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent occurrence in human cancers and a major promoter of chemotherapeutic resistance. Inhibition of one downstream target in this pathway, mTORC1, has shown potential to improve chemosensitivity. However, the mecha...
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| Main Authors: | , , , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2008
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2504845/ https://ncbi.nlm.nih.gov/pubmed/18664580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804821105 |
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