mTORC1 promotes survival through translational control of Mcl-1

Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent occurrence in human cancers and a major promoter of chemotherapeutic resistance. Inhibition of one downstream target in this pathway, mTORC1, has shown potential to improve chemosensitivity. However, the mecha...

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Autori principali: Mills, John R., Hippo, Yoshitaka, Robert, Francis, Chen, Samuel M. H., Malina, Abba, Lin, Chen-Ju, Trojahn, Ulrike, Wendel, Hans-Guido, Charest, Al, Bronson, Roderick T., Kogan, Scott C., Nadon, Robert, Housman, David E., Lowe, Scott W., Pelletier, Jerry
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504845/
https://ncbi.nlm.nih.gov/pubmed/18664580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804821105
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