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Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling

Nutritional excess and hyperlipidemia increase the heart’s susceptibility to ischemic injury. Mammalian target of rapamycin (mTOR) controls the cellular response to nutritional status and may play a role in ischemic injury. To explore the effect of hypercholesterolemia on cardiac mTOR signaling, we...

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Main Authors: Glazer, Hilary P., Osipov, Robert M., Clements, Richard T., Sellke, Frank W., Bianchi, Cesario
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308015/
https://ncbi.nlm.nih.gov/pubmed/19395857
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