New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise

por Bohl, Stephan R., Bullinger, Lars, Rücker, Frank G.
Publicado en Int J Mol Sci (2019)

Targeted therapies through microRNAs: pulp or fiction?

por Langer, Christian, Rücker, Frank G., Buske, Christian, Döhner, Hartmut, Kuchenbauer, Florian
Publicado 2012

CD95 Ligand (CD95L) in Normal Human Lymphoid Tissues : A Subset of Plasma Cells Are Prominent Producers of CD95L

por Sträter, Jörn, Mariani, Sara M., Walczak, Henning, Rücker, Frank G., Leithäuser, Frank, Krammer, Peter H., Möller, Peter
Publicado 1999

Rescue of Non-Informative Circulating Tumor DNA to Monitor the Mutational Landscape in NSCLC

por Mayer, Stefanie, Schmidtke-Schrezenmeier, Gerlinde, Buske, Christian, Rücker, Frank G., Barth, Thomas F.E., Möller, Peter, Marienfeld, Ralf
Publicado en Cancers (Basel) (2020)

Functional Classification of TP53 Mutations in Acute Myeloid Leukemia

por Dutta, Sayantanee, Pregartner, Gudrun, Rücker, Frank G., Heitzer, Ellen, Zebisch, Armin, Bullinger, Lars, Berghold, Andrea, Döhner, Konstanze, Sill, Heinz
Publicado en Cancers (Basel) (2020)

Clinical implications of subclonal TP53 mutations in acute myeloid leukemia

por Prochazka, Katharina T., Pregartner, Gudrun, Rücker, Frank G., Heitzer, Ellen, Pabst, Gabriel, Wölfler, Albert, Zebisch, Armin, Berghold, Andrea, Döhner, Konstanze, Sill, Heinz
Publicado en Haematologica (2019)

Molecular dissection of valproic acid effects in acute myeloid leukemia identifies predictive networks

por Rücker, Frank G., Lang, Katharina M., Fütterer, Markus, Komarica, Vladimir, Schmid, Mathias, Döhner, Hartmut, Schlenk, Richard F., Döhner, Konstanze, Knudsen, Steen, Bullinger, Lars
Publicado en Epigenetics (2016)

Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype

por Rücker, Frank G., Dolnik, Anna, Blätte, Tamara J., Teleanu, Veronica, Ernst, Aurélie, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze, Bullinger, Lars
Publicado en Haematologica (2018)

Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype

por Feurstein, Simone, Rücker, Frank G, Bullinger, Lars, Hofmann, Winfried, Manukjan, Georgi, Göhring, Gudrun, Lehmann, Ulrich, Heuser, Michael, Ganser, Arnold, Döhner, Konstanze, Schlegelberger, Brigitte, Steinemann, Doris
Publicado 2014

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis

por Scholl, Claudia, Bansal, Dimple, Döhner, Konstanze, Eiwen, Karina, Huntly, Brian J.P., Lee, Benjamin H., Rücker, Frank G., Schlenk, Richard F., Bullinger, Lars, Döhner, Hartmut, Gilliland, D. Gary, Fröhling, Stefan
Publicado 2007

Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia

por Russ, Annika C., Sander, Sandrine, Lück, Sonja C., Lang, Katharina M., Bauer, Marion, Rücker, Frank G., Kestler, Hans A., Schlenk, Richard F., Döhner, Hartmut, Holzmann, Karlheinz, Döhner, Konstanze, Bullinger, Lars
Publicado 2011

Genome-wide genotyping of acute myeloid leukemia with translocation t(9;11)(p22;q23) reveals novel recurrent genomic alterations

por Kühn, Michael W.M., Bullinger, Lars, Gröschel, Stefan, Krönke, Jan, Edelmann, Jennifer, Rücker, Frank G., Eiwen, Karina, Paschka, Peter, Gaidzik, Verena I., Holzmann, Karlheinz, Schlenk, Richard F., Döhner, Hartmut, Döhner, Konstanze
Publicado 2014

Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib

por Böhm, Michael J., Marienfeld, Ralf, Jäger, Daniela, Mellert, Kevin, von Witzleben, Adrian, Brüderlein, Silke, Wittau, Mathias, von Baer, Alexandra, Schultheiss, Markus, Mayer-Steinacker, Regine, Rücker, Frank G., Möller, Peter, Bullinger, Lars, Barth, Thomas F. E.
Publicado en Sarcoma (2019)

Protein phosphatase 4 regulatory subunit 2 (PPP4R2) is recurrently deleted in acute myeloid leukemia and required for efficient DNA double strand break repair

por Herzig, Julia K., Bullinger, Lars, Tasdogan, Alpaslan, Zimmermann, Philipp, Schlegel, Martin, Teleanu, Veronica, Weber, Daniela, Rücker, Frank G., Paschka, Peter, Dolnik, Anna, Schneider, Edith, Kuchenbauer, Florian, Heidel, Florian H., Buske, Christian, Döhner, Hartmut, Döhner, Konstanze, Gaidzik, Verena I.
Publicado en Oncotarget (2017)

Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia

por Uckelmann, Hannah J., Kim, Stephanie M., Wong, Eric M., Hatton, Charles, Giovinazzo, Hugh, Gadrey, Jayant Y., Krivtsov, Andrei V., Rücker, Frank G., Döhner, Konstanze, McGeehan, Gerard M., Levine, Ross L., Bullinger, Lars, Vassiliou, George S., Armstrong, Scott A.
Publicado en Science (2020)

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation

por Cocciardi, Sibylle, Dolnik, Anna, Kapp-Schwoerer, Silke, Rücker, Frank G., Lux, Susanne, Blätte, Tamara J., Skambraks, Sabrina, Krönke, Jan, Heidel, Florian H., Schnöder, Tina M., Corbacioglu, Andrea, Gaidzik, Verena I., Paschka, Peter, Teleanu, Veronica, Göhring, Gudrun, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Weber, Daniela, Sträng, Eric, Kestler, Hans A., Döhner, Hartmut, Bullinger, Lars, Döhner, Konstanze
Publicado en Nat Commun (2019)

Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication

por Jahn, Nikolaus, Terzer, Tobias, Sträng, Eric, Dolnik, Anna, Cocciardi, Sibylle, Panina, Ekaterina, Corbacioglu, Andrea, Herzig, Julia, Weber, Daniela, Schrade, Anika, Götze, Katharina, Schröder, Thomas, Lübbert, Michael, Wellnitz, Dominique, Koller, Elisabeth, Schlenk, Richard F., Gaidzik, Verena I., Paschka, Peter, Rücker, Frank G., Heuser, Michael, Thol, Felicitas, Ganser, Arnold, Benner, Axel, Döhner, Hartmut, Bullinger, Lars, Döhner, Konstanze
Publicado en Blood Adv (2020)

Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)

por Agrawal, Mridul, Schwarz, Peggy, Giaimo, Benedetto Daniele, Bedzhov, Ivan, Corbacioglu, Andrea, Weber, Daniela, Gaidzik, Verena I., Jahn, Nikolaus, Rücker, Frank G., Schroeder, Thomas, Kindler, Thomas, Wattad, Mohammed, Götze, Katharina, Lübbert, Michael, Salwender, Hans, Ringhoffer, Mark, Lange, Elisabeth, Koller, Elisabeth, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Bullinger, Lars, Paschka, Peter, Döhner, Hartmut, Geiger, Hartmut, Borggrefe, Tilman, Döhner, Konstanze, Oswald, Franz
Publicado en Leukemia (2019)

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

por Boettcher, Steffen, Miller, Peter G., Sharma, Rohan, McConkey, Marie, Leventhal, Matthew, Krivtsov, Andrei V., Giacomelli, Andrew O., Wong, Waihay, Kim, Jesi, Chao, Sherry, Kurppa, Kari J., Yang, Xiaoping, Milenkowic, Kirsten, Piccioni, Federica, Root, David E., Rücker, Frank G., Flamand, Yael, Neuberg, Donna, Lindsley, R. Coleman, Jänne, Pasi A., Hahn, William C., Jacks, Tyler, Döhner, Hartmut, Armstrong, Scott A., Ebert, Benjamin L.
Publicado en Science (2019)

Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin

por Schmalbrock, Laura K., Dolnik, Anna, Cocciardi, Sibylle, Sträng, Eric, Theis, Frauke, Jahn, Nikolaus, Panina, Ekaterina, Blätte, Tamara J., Herzig, Julia, Skambraks, Sabrina, Rücker, Frank G., Gaidzik, Verena I., Paschka, Peter, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Schroeder, Thomas, Lübbert, Michael, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Larson, Richard A., Ganser, Arnold, Stunnenberg, Hendrik G., Minucci, Saverio, Stone, Richard M., Bloomfield, Clara D., Döhner, Hartmut, Döhner, Konstanze, Bullinger, Lars
Publicado en Blood (2021)