Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia

The initiating mutations that contribute to cancer development are sometimes present in pre-malignant cells. Whether therapies targeting these mutations can eradicate pre-malignant cells is unclear. Acute myeloid leukemia (AML) is an attractive system for investigating the effect of preventative tre...

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Publicado en:Science
Autores principales: Uckelmann, Hannah J., Kim, Stephanie M., Wong, Eric M., Hatton, Charles, Giovinazzo, Hugh, Gadrey, Jayant Y., Krivtsov, Andrei V., Rücker, Frank G., Döhner, Konstanze, McGeehan, Gerard M., Levine, Ross L., Bullinger, Lars, Vassiliou, George S., Armstrong, Scott A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754791/
https://ncbi.nlm.nih.gov/pubmed/32001657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax5863
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