Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia

The initiating mutations that contribute to cancer development are sometimes present in pre-malignant cells. Whether therapies targeting these mutations can eradicate pre-malignant cells is unclear. Acute myeloid leukemia (AML) is an attractive system for investigating the effect of preventative tre...

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Udgivet i:Science
Main Authors: Uckelmann, Hannah J., Kim, Stephanie M., Wong, Eric M., Hatton, Charles, Giovinazzo, Hugh, Gadrey, Jayant Y., Krivtsov, Andrei V., Rücker, Frank G., Döhner, Konstanze, McGeehan, Gerard M., Levine, Ross L., Bullinger, Lars, Vassiliou, George S., Armstrong, Scott A.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754791/
https://ncbi.nlm.nih.gov/pubmed/32001657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax5863
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