Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia

The initiating mutations that contribute to cancer development are sometimes present in pre-malignant cells. Whether therapies targeting these mutations can eradicate pre-malignant cells is unclear. Acute myeloid leukemia (AML) is an attractive system for investigating the effect of preventative tre...

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發表在:Science
Main Authors: Uckelmann, Hannah J., Kim, Stephanie M., Wong, Eric M., Hatton, Charles, Giovinazzo, Hugh, Gadrey, Jayant Y., Krivtsov, Andrei V., Rücker, Frank G., Döhner, Konstanze, McGeehan, Gerard M., Levine, Ross L., Bullinger, Lars, Vassiliou, George S., Armstrong, Scott A.
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754791/
https://ncbi.nlm.nih.gov/pubmed/32001657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax5863
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