Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype

BACKGROUND: Acute myeloid leukemia with complex karyotype (CK-AML) is a distinct biological entity associated with a very poor outcome. Since complex karyotypes frequently contain deletions of the chromosomal region 12p13 encompassing the tumor suppressor genes ETV6 and CDKN1B, we aimed to unravel t...

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Autori principali: Feurstein, Simone, Rücker, Frank G, Bullinger, Lars, Hofmann, Winfried, Manukjan, Georgi, Göhring, Gudrun, Lehmann, Ulrich, Heuser, Michael, Ganser, Arnold, Döhner, Konstanze, Schlegelberger, Brigitte, Steinemann, Doris
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4168160/
https://ncbi.nlm.nih.gov/pubmed/25213837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-784
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