The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells

The cytotoxic farnesyl transferase inhibitor BMS-214662 has been shown to potently induce mitochondrial apoptosis in primitive CD34+ chronic myeloid leukaemia (CML) stem/progenitor cells. Here, to enhance the BMS-214662 apoptotic effect, we further targeted the RAS-MEK-ERK pathway, downstream of BCR...

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Bibliografiske detaljer
Main Authors: Pellicano, Francesca, Šimara, Pavel, Sinclair, Amy, Helgason, G. Vignir, Copland, Mhairi, Grant, Steven, Holyoake, Tessa Laurie
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643208/
https://ncbi.nlm.nih.gov/pubmed/21483442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.67
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