MEK-inhibitor PD184352 enhances the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922: the role of cell type and drug-irradiation schedule

Targeting MEK protein in cancer cells usually leads to acquired resistance to MEK inhibitors and activation of the prosurvival protein Akt. Since both MEK and Akt are clients of the Hsp90 chaperone system, the present study explores the responses of irradiated lung carcinoma A549 and glioblastoma SN...

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Опубликовано в: :Oncotarget
Главные авторы: Grabenbauer, Felix, Katzer, Astrid, Sisario, Dmitri, Memmel, Simon, Flentje, Michael, Sukhorukov, Vladimir L., Djuzenova, Cholpon S.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2018
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324777/
https://ncbi.nlm.nih.gov/pubmed/30647839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26436
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