hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival

Chronic myeloid leukemia (CML) stem/progenitor cells (SPCs) express a transcriptional program characteristic of proliferation, yet can achieve and maintain quiescence. Understanding the mechanisms by which leukemic SPCs maintain quiescence will help to clarify how they persist during long-term targe...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Pellicano, Francesca, Park, Laura, Hopcroft, Lisa E. M., Shah, Mansi M., Jackson, Lorna, Scott, Mary T., Clarke, Cassie J., Sinclair, Amy, Abraham, Sheela A., Hair, Alan, Helgason, G. Vignir, Aspinall-O’Dea, Mark, Bhatia, Ravi, Leone, Gustavo, Kranc, Kamil R., Whetton, Anthony D., Holyoake, Tessa L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027092/
https://ncbi.nlm.nih.gov/pubmed/29437554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-783845
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