Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia

Targeting the Hedgehog (Hh) pathway represents a potential leukaemia stem cell (LSC)-directed therapy which may compliment tyrosine kinase inhibitors (TKIs) to eradicate LSC in chronic phase (CP) chronic myeloid leukaemia (CML). We set out to elucidate the role of Hh signaling in CP-CML and determin...

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Published in:Sci Rep
Main Authors: Irvine, David A., Zhang, Bin, Kinstrie, Ross, Tarafdar, Anuradha, Morrison, Heather, Campbell, Victoria L., Moka, Hothri A., Ho, Yinwei, Nixon, Colin, Manley, Paul W., Wheadon, Helen, Goodlad, John R., Holyoake, Tessa L., Bhatia, Ravi, Copland, Mhairi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860619/
https://ncbi.nlm.nih.gov/pubmed/27157927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25476
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