Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia

Targeting the Hedgehog (Hh) pathway represents a potential leukaemia stem cell (LSC)-directed therapy which may compliment tyrosine kinase inhibitors (TKIs) to eradicate LSC in chronic phase (CP) chronic myeloid leukaemia (CML). We set out to elucidate the role of Hh signaling in CP-CML and determin...

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Publicado en:Sci Rep
Main Authors: Irvine, David A., Zhang, Bin, Kinstrie, Ross, Tarafdar, Anuradha, Morrison, Heather, Campbell, Victoria L., Moka, Hothri A., Ho, Yinwei, Nixon, Colin, Manley, Paul W., Wheadon, Helen, Goodlad, John R., Holyoake, Tessa L., Bhatia, Ravi, Copland, Mhairi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860619/
https://ncbi.nlm.nih.gov/pubmed/27157927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25476
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