NVP-LDE225, a Potent and Selective SMOOTHENED Antagonist Reduces Melanoma Growth In Vitro and In Vivo

Melanoma is one of the most aggressive cancers and its incidence is increasing worldwide. So far there are no curable therapies especially after metastasis. Due to frequent mutations in members of the mitogen-activated protein kinase (MAPK) signaling pathway, this pathway is constitutively active in...

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Autors principals: Jalili, Ahmad, Mertz, Kirsten D., Romanov, Julia, Wagner, Christine, Kalthoff, Frank, Stuetz, Anton, Pathria, Gaurav, Gschaider, Melanie, Stingl, Georg, Wagner, Stephan N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728309/
https://ncbi.nlm.nih.gov/pubmed/23935925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069064
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