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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
[Image: see text] The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was performed, and the lead structure (1) was identified as an inhibitor of the Hh pathway via antagonism of the Smoothened rece...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007689/ https://ncbi.nlm.nih.gov/pubmed/24900187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1000307 |
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