Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research

od Tuntland, Tove, Ethell, Brian, Kosaka, Takatoshi, Blasco, Francesca, Zang, Richard Xu, Jain, Monish, Gould, Ty, Hoffmaster, Keith
Izdano 2014

TrkB Inhibition by GNF-4256 Slows Growth and Enhances Chemotherapeutic Efficacy in Neuroblastoma Xenografts

od Croucher, Jamie L., Iyer, Radhika, Li, Nanxin, Molteni, Valentina, Loren, Jon, Gordon, W. Perry, Tuntland, Tove, Liu, Bo, Brodeur, Garrett M.
Izdano u Cancer Chemother Pharmacol (2014)

Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease

od Khare, Shilpi, Liu, Xianzhong, Stinson, Monique, Rivera, Ianne, Groessl, Todd, Tuntland, Tove, Yeh, Vince, Wen, Ben, Molteni, Valentina, Glynne, Richard, Supek, Frantisek
Izdano u Antimicrob Agents Chemother (2015)

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

od Rao, Srinivasa P S, Lakshminarayana, Suresh B, Jiricek, Jan, Kaiser, Marcel, Ritchie, Ryan, Myburgh, Elmarie, Supek, Frantisek, Tuntland, Tove, Nagle, Advait, Molteni, Valentina, Mäser, Pascal, Mottram, Jeremy C, Barrett, Michael P, Diagana, Thierry T
Izdano u Trop Med Infect Dis (2020)

A Type-II Kinase Inhibitor Capable of Inhibiting the T315I “Gatekeeper” mutant of Bcr-Abl

od Choi, Hwan Geun, Ren, Pingda, Adrian, Francisco, Sun, Fangxian, Lee, Hyun Soo, Wang, Xia, Ding, Qiang, Zhang, Guobao, Zhang, Yongping, Liu, Yi, Tuntland, Tove, Warmuth, Markus, Manley, Paul W., Mestan, Jürgen, Gray, Nathanael S, Sim, Taebo
Izdano 2010

Enhanced Proteolytic Clearance of Plasma Aβ by Peripherally Administered Neprilysin Does Not Result in Reduced Levels of Brain Aβ in Mice

od Walker, John R., Pacoma, Reynand, Watson, James, Ou, Weijia, Alves, Juliano, Mason, Daniel E., Peters, Eric C., Urbina, Hugo D., Welzel, Gus, Althage, Alana, Liu, Bo, Tuntland, Tove, Jacobson, Laura H., Harris, Jennifer L., Schumacher, Andrew M.
Izdano u J Neurosci (2013)

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

od Pan, Shifeng, Gray, Nathanael S., Gao, Wenqi, Mi, Yuan, Fan, Yi, Wang, Xing, Tuntland, Tove, Che, Jianwei, Lefebvre, Sophie, Chen, Yu, Chu, Alan, Hinterding, Klaus, Gardin, Anne, End, Peter, Heining, Peter, Bruns, Christian, Cooke, Nigel G., Nuesslein-Hildesheim, Barbara
Izdano 2013

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models

od Albaugh, Pam, Fan, Yi, Mi, Yuan, Sun, Fangxian, Adrian, Francisco, Li, Nanxin, Jia, Yong, Sarkisova, Yelena, Kreusch, Andreas, Hood, Tami, Lu, Min, Liu, Guoxun, Huang, Shenlin, Liu, Zuosheng, Loren, Jon, Tuntland, Tove, Karanewsky, Donald S., Seidel, H. Martin, Molteni, Valentina
Izdano 2012

Cell-based optimization of novel benzamides as potential antimalarial leads

od Wu, Tao, Nagle, Advait, Sakata, Tomoyo, Henson, Kerstin, Borboa, Rachel, Chen, Zhong, Kuhen, Kelli, Plouffe, David, Winzeler, Elizabeth, Adrian, Francisco, Tuntland, Tove, Chang, Jonathan, Simerson, Susan, Howard, Steven, Ek, Jared, Isbell, John, Deng, Xianming, Gray, Nathanael S., Tully, David C., Chatterjee, Arnab K.
Izdano 2009

Dual ALK and CDK4/6 inhibition demonstrates synergy against neuroblastoma

od Wood, Andrew C., Krytska, Kateryna, Ryles, Hannah, Infarinato, Nicole, Sano, Renata, Hansel, Theodore, Hart, Lori, King, Frederick J., Smith, Timothy R., Ainscow, Edward, Grandinetti, Kathryn B., Tuntland, Tove, Kim, Sunkyu, Caponigro, Giordano, He, You Qun, Krupa, Shiva, Li, Nanxin, Harris, Jennifer L., Mossé, Yaël P.
Izdano u Clin Cancer Res (2016)

A small molecule accelerates neuronal differentiation in the adult rat

od Wurdak, Heiko, Zhu, Shoutian, Min, Kyung Hoon, Aimone, Lindsey, Lairson, Luke L., Watson, James, Chopiuk, Gregory, Demas, James, Charette, Bradley, Halder, Rajkumar, Weerapana, Eranthie, Cravatt, Benjamin F., Cline, Hollis T., Peters, Eric C., Zhang, Jay, Walker, John R., Wu, Chunlei, Chang, Jonathan, Tuntland, Tove, Cho, Charles Y., Schultz, Peter G.
Izdano 2010

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

od Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P., Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C., Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F., Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion
Izdano 2010

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

od Nagle, Advait, Wu, Tao, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Liu, Bo, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Chuan, Tiffany, Alper, Philip B., Fischli, Christoph, Brun, Reto, Lakshminarayana, Suresh B., Rottmann, Matthias, Diagana, Thierry T., Winzeler, Elizabeth A., Glynne, Richard, Tully, David C., Chatterjee, Arnab K.
Izdano 2012

Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases

od He, Xiaohui, Da Ros, Sara, Nelson, John, Zhu, Xuefeng, Jiang, Tao, Okram, Barun, Jiang, Songchun, Michellys, Pierre-Yves, Iskandar, Maya, Espinola, Sheryll, Jia, Yong, Bursulaya, Badry, Kreusch, Andreas, Gao, Mu-Yun, Spraggon, Glen, Baaten, Janine, Clemmer, Leah, Meeusen, Shelly, Huang, David, Hill, Robert, Nguyen-Tran, Vân, Fathman, John, Liu, Bo, Tuntland, Tove, Gordon, Perry, Hollenbeck, Thomas, Ng, Kenneth, Shi, Jian, Bordone, Laura, Liu, Hong
Izdano u ACS Med Chem Lett (2017)

Targeting wild-type and T315I Bcr-Abl by combining allosteric with ATP-site inhibitors

od Zhang, Jianming, Adrián, Francisco J., Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Li, Allen G., Iacob, Roxana E., Sim, Taebo, Powers, John, Dierks, Christine, Sun, Fangxian, Guo, Gui-Rong, Ding, Qiang, Okram, Barun, Choi, Yongmun, Wojciechowski, Amy, Deng, Xianming, Liu, Guoxun, Fendrich, Gabriele, Strauss, Andre, Vajpai, Navratna, Grzesiek, Stephan, Tuntland, Tove, Liu, Yi, Bursulaya, Badry, Azam, Mohammad, Manley, Paul W., Engen, John R., Daley, George Q., Warmuth, Markus, Gray, Nathanael S.
Izdano 2010

(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors

od Choi, Ha-Soon, Rucker, Paul V., Wang, Zhicheng, Fan, Yi, Albaugh, Pamela, Chopiuk, Greg, Gessier, Francois, Sun, Fangxian, Adrian, Francisco, Liu, Guoxun, Hood, Tami, Li, Nanxin, Jia, Yong, Che, Jianwei, McCormack, Susan, Li, Allen, Li, Jie, Steffy, Auzon, Culazzo, AnneMarie, Tompkins, Celine, Phung, Van, Kreusch, Andreas, Lu, Min, Hu, Bin, Chaudhary, Apurva, Prashad, Mahavir, Tuntland, Tove, Liu, Bo, Harris, Jennifer, Seidel, H. Martin, Loren, Jon, Molteni, Valentina
Izdano u ACS Med Chem Lett (2015)

Lead Optimization of Imidazopyrazines: A New Class of Antimalarial with Activity on Plasmodium Liver Stages

od Zou, Bin, Nagle, Advait, Chatterjee, Arnab K., Leong, Seh Yong, Tan, Liying Jocelyn, Sim, Wei Lin Sandra, Mishra, Pranab, Guntapalli, Prasuna, Tully, David C., Lakshminarayana, Suresh B., Lim, Chek Shik, Tan, Yong Cheng, Abas, Siti Nurdiana, Bodenreider, Christophe, Kuhen, Kelli L., Gagaring, Kerstin, Borboa, Rachel, Chang, Jonathan, Li, Chun, Hollenbeck, Thomas, Tuntland, Tove, Zeeman, Anne-Marie, Kocken, Clemens H. M., McNamara, Case, Kato, Nobutaka, Winzeler, Elizabeth A., Yeung, Bryan K. S., Diagana, Thierry T., Smith, Paul W., Roland, Jason
Izdano 2014

Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

od Wu, Tao, Nagle, Advait, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Goh, Anne, Lakshminarayana, Suresh B., Wu, Jeanette, Ang, Hui Qing, Zeng, Peiting, Kang, Min Low, Tan, William, Tan, Maria, Ye, Nicole, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Fischli, Christoph, Brun, Reto, Rottmann, Matthias, Dartois, Veronique, Keller, Thomas, Diagana, Thierry, Winzeler, Elizabeth, Glynne, Richard, Tully, David C., Chatterjee, Arnab K.
Izdano u J Med Chem (2011)

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

od Khare, Shilpi, Nagle, Advait S., Biggart, Agnes, Lai, Yin H., Liang, Fang, Davis, Lauren C., Barnes, S. Whitney, Mathison, Casey J. N., Myburgh, Elmarie, Gao, Mu-Yun, Gillespie, J. Robert, Liu, Xianzhong, Tan, Jocelyn L., Stinson, Monique, Rivera, Ianne C., Ballard, Jaime, Yeh, Vince, Groessl, Todd, Federe, Glenn, Koh, Hazel X. Y., Venable, John D., Bursulaya, Badry, Shapiro, Michael, Mishra, Pranab K., Spraggon, Glen, Brock, Ansgar, Mottram, Jeremy C., Buckner, Frederick S., Rao, Srinivasa P. S., Wen, Ben G., Walker, John R., Tuntland, Tove, Molteni, Valentina, Glynne, Richard J., Supek, Frantisek
Izdano u Nature (2016)

Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery

od Meister, Stephan, Plouffe, David M, Kuhen, Kelli L, Bonamy, Ghislain MC, Wu, Tao, Barnes, S Whitney, Bopp, Selina E, Borboa, Rachel, Bright, A Taylor, Che, Jianwei, Cohen, Steve, Dharia, Neekesh V, Gagaring, Kerstin, Gettayacamin, Montip, Gordon, Perry, Groessl, Todd, Kato, Nobutaka, Lee, Marcus CS, McNamara, Case W, Fidock, David A, Nagle, Advait, Nam, Tae-gyu, Richmond, Wendy, Roland, Jason, Rottmann, Matthias, Zhou, Bin, Froissard, Patrick, Glynne, Richard J, Mazier, Dominique, Sattabongkot, Jetsumon, Schultz, Peter G, Tuntland, Tove, Walker, John R, Zhou, Yingyao, Chatterjee, Arnab, Diagana, Thierry T, Winzeler, Elizabeth A
Izdano 2011