Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data

Por Heimbach, Tycho, Lakshminarayana, Suresh B., Hu, Wenyu, He, Handan
Publicado em 2009

Differences in the pharmacokinetics of currently approved antimalarial drugs in uncomplicated malaria patients compared to healthy subjects

Por Jain, Jay Prakash, Lakshminarayana, Suresh B, Lefèvre, Gilbert, Sivasubramanian, Rama, Blasco, Francesca, Sunkara, Gangadhar
Publicado em 2012

Mutations in Genes for the F(420) Biosynthetic Pathway and a Nitroreductase Enzyme Are the Primary Resistance Determinants in Spontaneous In Vitro-Selected PA-824-Resistant Mutants...

Por Haver, Hana L., Chua, Adeline, Ghode, Pramila, Lakshminarayana, Suresh B., Singhal, Amit, Mathema, Barun, Wintjens, René, Bifani, Pablo
Publicado no Antimicrob Agents Chemother (2015)

Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model

Por Lakshminarayana, Suresh B., Freymond, Céline, Fischli, Christoph, Yu, Jing, Weber, Sebastian, Goh, Anne, Yeung, Bryan K. S., Ho, Paul C., Dartois, Véronique, Diagana, Thierry T., Rottmann, Matthias, Blasco, Francesca
Publicado no Antimicrob Agents Chemother (2015)

Inhibition of Dengue Virus by an Ester Prodrug of an Adenosine Analog

Por Chen, Yen-Liang, Yin, Zheng, Lakshminarayana, Suresh B., Qing, Min, Schul, Wouter, Duraiswamy, Jeyaraj, Kondreddi, Ravinder Reddi, Goh, Anne, Xu, Hao Ying, Yip, Andy, Liu, Boping, Weaver, Margaret, Dartois, Veronique, Keller, Thomas H., Shi, Pei-Yong
Publicado em 2010

Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

Por Lakshminarayana, Suresh B., Boshoff, Helena I. M., Cherian, Joseph, Ravindran, Sindhu, Goh, Anne, Jiricek, Jan, Nanjundappa, Mahesh, Nayyar, Amit, Gurumurthy, Meera, Singh, Ramandeep, Dick, Thomas, Blasco, Francesca, Barry, Clifton E., Ho, Paul C., Manjunatha, Ujjini H.
Publicado em 2014

PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites

Por Zeeman, Anne-Marie, Lakshminarayana, Suresh B., van der Werff, Nicole, Klooster, Els J., Voorberg-van der Wel, Annemarie, Kondreddi, Ravinder R., Bodenreider, Christophe, Simon, Oliver, Sauerwein, Robert, Yeung, Bryan K. S., Diagana, Thierry T., Kocken, Clemens H. M.
Publicado no Antimicrob Agents Chemother (2016)

A Translation Inhibitor That Suppresses Dengue Virus In Vitro and In Vivo

Por Wang, Qing-Yin, Kondreddi, Ravinder Reddy, Xie, Xuping, Rao, Ranga, Nilar, Shahul, Xu, Hao Ying, Qing, Min, Chang, David, Dong, Hongping, Yokokawa, Fumiaki, Lakshminarayana, Suresh B., Goh, Anne, Schul, Wouter, Kramer, Laura, Keller, Thomas H., Shi, Pei-Yong
Publicado em 2011

Structure-Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-...

Por Cherian, Joseph, Choi, Inhee, Nayyar, Amit, Manjunatha, Ujjini H., Mukherjee, Tathagata, Lee, Yong Sok, Boshoff, Helena I., Singh, Ramandeep, Ha, Young Hwan, Goodwin, Michael, Lakshminarayana, Suresh B., Niyomrattanakit, Pornwaratt, Jiricek, Jan, Ravindran, Sindhu, Dick, Thomas, Keller, Thomas H., Dartois, Veronique, Barry, Clifton E.
Publicado em 2011

Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N′6′-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

Por Nzila, Alexis, Rottmann, Matthias, Chitnumsub, Penchit, Kiara, Stevens M., Kamchonwongpaisan, Sumalee, Maneeruttanarungroj, Cherdsak, Taweechai, Supannee, Yeung, Bryan K. S., Goh, Anne, Lakshminarayana, Suresh B., Zou, Bin, Wong, Josephine, Ma, Ngai Ling, Weaver, Margaret, Keller, Thomas H., Dartois, Veronique, Wittlin, Sergio, Brun, Reto, Yuthavong, Yongyuth, Diagana, Thierry T.
Publicado em 2010

Combination of alpha-glucosidase inhibitor and ribavirin for the treatment of Dengue virus infection in vitro and in vivo

Por Chang, Jinhong, Schul, Wouter, Butters, Terry D., Yip, Andy, Liu, Boping, Goh, Anne, Lakshminarayana, Suresh B., Alonzi, Dominic, Reinkensmeier, Gabriele, Pan, Xiaoben, Qu, Xiaowang, Weidner, Jessica M., Wang, Lijuan, Yu, Wenquan, Borune, Nigel, Kinch, Mark A., Rayahin, Jamie E., Moriarty, Robert, Xu, Xiaodong, Shi, Pei-Yong, Guo, Ju-Tao, Block, Timothy M.
Publicado em 2010

Discovery of Dengue Virus NS4B Inhibitors

Por Wang, Qing-Yin, Dong, Hongping, Zou, Bin, Karuna, Ratna, Wan, Kah Fei, Zou, Jing, Susila, Agatha, Yip, Andy, Shan, Chao, Yeo, Kim Long, Xu, Haoying, Ding, Mei, Chan, Wai Ling, Gu, Feng, Seah, Peck Gee, Liu, Wei, Lakshminarayana, Suresh B., Kang, CongBao, Lescar, Julien, Blasco, Francesca, Smith, Paul W., Shi, Pei-Yong
Publicado no J Virol (2015)

Direct inhibitors of InhA active against Mycobacterium tuberculosis

Por Manjunatha, Ujjini H., Rao, Srinivasa P. S., Kondreddi, Ravinder Reddy, Noble, Christian G., Camacho, Luis R., Tan, Bee H., Ng, Seow H., Ng, Pearly Shuyi, Ma, N. L., Lakshminarayana, Suresh B., Herve, Maxime, Barnes, S. Whitney, Yu, Weixuan, Kuhen, Kelli, Blasco, Francesca, Beer, David, Walker, John R., Tonge, Peter J., Glynne, Richard, Smith, Paul W., Diagana, Thierry T.
Publicado no Sci Transl Med (2015)

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

Por Manjunatha, Ujjini H., Vinayak, Sumiti, Zambriski, Jennifer A., Chao, Alexander T., Sy, Tracy, Noble, Christian G., Bonamy, Ghislain M. C., Kondreddi, Ravinder R., Zou, Bin, Gedeck, Peter, Brooks, Carrie F., Herbert, Gillian T., Sateriale, Adam, Tandel, Jayesh, Noh, Susan, Lakshminarayana, Suresh B., Lim, Siau H., Goodman, Laura B., Bodenreider, Christophe, Feng, Gu, Zhang, Lijun, Blasco, Francesca, Wagner, Juergen, Leong, F. Joel, Striepen, Boris, Diagana, Thierry T.
Publicado no Nature (2017)

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

Por Nagle, Advait, Wu, Tao, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Liu, Bo, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Chuan, Tiffany, Alper, Philip B., Fischli, Christoph, Brun, Reto, Lakshminarayana, Suresh B., Rottmann, Matthias, Diagana, Thierry T., Winzeler, Elizabeth A., Glynne, Richard, Tully, David C., Chatterjee, Arnab K.
Publicado em 2012

Spiroindolones, a new and potent chemotype for the treatment of malaria

Por Rottmann, Matthias, McNamara, Case, Yeung, Bryan K. S., Lee, Marcus C. S., Zou, Bin, Russell, Bruce, Seitz, Patrick, Plouffe, David M., Dharia, Neekesh V., Tan, Jocelyn, Cohen, Steven B., Spencer, Kathryn R., González-Páez, Gonzalo E., Lakshminarayana, Suresh B., Goh, Anne, Suwanarusk, Rossarin, Jegla, Tim, Schmitt, Esther K., Beck, Hans-Peter, Brun, Reto, Nosten, Francois, Renia, Laurent, Dartois, Veronique, Keller, Thomas H., Fidock, David A., Winzeler, Elizabeth A., Diagana, Thierry T.
Publicado em 2010

Corrrection to Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Novel Antitubercular Agents

Por Yokokawa, Fumiaki, Wang, Gang, Chan, Wai Ling, Ang, Shi Hua, Wong, Josephine, Ma, Ida, Rao, Srinivasa P S, Manjunatha, Ujjini, Lakshminarayana, Suresh B, Herve, Maxime, Kounde, Cyrille, Tan, Bee Huat, Thayalan, Pamela, Dick, Thomas, Ng, Seow Hwee, Nanjundappa, Mahesh, Ravindran, Sindhu, Gee, Peck, Tan, Maria, Wei, Liu, Goh, Anne, Chen, Pei-Yu, Lee, Kok Sin, Zhang, Chen, Wagner, Trixie, Dix, Ina, Chatterjee, Arnab, Pethe, Kevin, Kuhen, Kelli, Glynne, Richard, Smith, Paul, Bifani, Pablo, Jiricek, Jan
Publicado em 2014

Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Antitubercular Agents

Por Yokokawa, Fumiaki, Wang, Gang, Chan, Wai Ling, Ang, Shi Hua, Wong, Josephine, Ma, Ida, Rao, Srinivasa P S, Manjunatha, Ujjini, Lakshminarayana, Suresh B, Herve, Maxime, Kounde, Cyrille, Tan, Bee Huat, Thayalan, Pamela, Ng, Seow Hwee, Nanjundappa, Mahesh, Ravindran, Sindhu, Gee, Peck, Tan, Maria, Wei, Liu, Goh, Anne, Chen, Pei-Yu, Lee, Kok Sin, Zhong, Chen, Wagner, Trixie, Dix, Ina, Chatterjee, Arnab K., Pethe, Kevin, Kuhen, Kelli, Glynne, Richard, Smith, Paul, Bifani, Pablo, Jiricek, Jan
Publicado em 2013

Lead Optimization of Imidazopyrazines: A New Class of Antimalarial with Activity on Plasmodium Liver Stages

Por Zou, Bin, Nagle, Advait, Chatterjee, Arnab K., Leong, Seh Yong, Tan, Liying Jocelyn, Sim, Wei Lin Sandra, Mishra, Pranab, Guntapalli, Prasuna, Tully, David C., Lakshminarayana, Suresh B., Lim, Chek Shik, Tan, Yong Cheng, Abas, Siti Nurdiana, Bodenreider, Christophe, Kuhen, Kelli L., Gagaring, Kerstin, Borboa, Rachel, Chang, Jonathan, Li, Chun, Hollenbeck, Thomas, Tuntland, Tove, Zeeman, Anne-Marie, Kocken, Clemens H. M., McNamara, Case, Kato, Nobutaka, Winzeler, Elizabeth A., Yeung, Bryan K. S., Diagana, Thierry T., Smith, Paul W., Roland, Jason
Publicado em 2014

An adenosine nucleoside inhibitor of dengue virus

Por Yin, Zheng, Chen, Yen-Liang, Schul, Wouter, Wang, Qing-Yin, Gu, Feng, Duraiswamy, Jeyaraj, Kondreddi, Ravinder Reddy, Niyomrattanakit, Pornwaratt, Lakshminarayana, Suresh B., Goh, Anne, Xu, Hao Ying, Liu, Wei, Liu, Boping, Lim, Joanne Y. H., Ng, Chuan Young, Qing, Min, Lim, Chin Chin, Yip, Andy, Wang, Gang, Chan, Wai Ling, Tan, Hui Pen, Lin, Kai, Zhang, Bo, Zou, Gang, Bernard, Kristen A., Garrett, Christine, Beltz, Karen, Dong, Min, Weaver, Margaret, He, Handan, Pichota, Arkadius, Dartois, Veronique, Keller, Thomas H., Shi, Pei-Yong
Publicado em 2009