A Method for Rapid Genetic Integration into Plasmodium falciparum Utilizing Mycobacteriophage Bxb1 Integrase

Por Adjalley, Sophie H., Lee, Marcus C.S., Fidock, David A.
Publicado em 2010

Inhibiting Endoplasmic Reticulum (ER)-associated Degradation of Misfolded Yor1p Does Not Permit ER Export Despite the Presence of a Diacidic Sorting Signal

Por Pagant, Silvere, Kung, Leslie, Dorrington, Mariana, Lee, Marcus C.S., Miller, Elizabeth A.
Publicado em 2007

Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif

Por Lee, Marcus C. S., Moura, Pedro A., Miller, Elizabeth A., Fidock, David A.
Publicado em 2008

Genomewide Analysis Reveals Novel Pathways Affecting Endoplasmic Reticulum Homeostasis, Protein Modification and Quality Control

Por Čopič, Alenka, Dorrington, Mariana, Pagant, Silvere, Barry, Justine, Lee, Marcus C. S., Singh, Indira, Hartman, John L., Miller, Elizabeth A.
Publicado em 2009

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

Por Adjalley, Sophie H., Johnston, Geoffrey L., Li, Tao, Eastman, Richard T., Ekland, Eric H., Eappen, Abraham G., Richman, Adam, Sim, B. Kim Lee, Lee, Marcus C. S., Hoffman, Stephen L., Fidock, David A.
Publicado em 2011

Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum

Por Gulati, Sonia, Ekland, Eric H., Ruggles, Kelly V., Chan, Robin B., Jayabalasingham, Bamini, Zhou, Bowen, Mantel, Pierre-Yves, Lee, Marcus C. S., Spottiswoode, Natasha, Coburn-Flynn, Olivia, Hjelmqvist, Daisy, Worgall, Tilla S., Marti, Matthias, Di Paolo, Gilbert, Fidock, David A.
Publicado no Cell Host Microbe (2015)

CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based...

Por Ng, Caroline L., Siciliano, Giulia, Lee, Marcus C. S., de Almeida, Mariana J., Corey, Victoria C., Bopp, Selina E., Bertuccini, Lucia, Wittlin, Sergio, Kasdin, Rachel G., Le Bihan, Amélie, Clozel, Martine, Winzeler, Elizabeth A., Alano, Pietro, Fidock, David A.
Publicado no Mol Microbiol (2016)

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

Por Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.
Publicado no Nat Commun (2017)

Spiroindolones, a new and potent chemotype for the treatment of malaria

Por Rottmann, Matthias, McNamara, Case, Yeung, Bryan K. S., Lee, Marcus C. S., Zou, Bin, Russell, Bruce, Seitz, Patrick, Plouffe, David M., Dharia, Neekesh V., Tan, Jocelyn, Cohen, Steven B., Spencer, Kathryn R., González-Páez, Gonzalo E., Lakshminarayana, Suresh B., Goh, Anne, Suwanarusk, Rossarin, Jegla, Tim, Schmitt, Esther K., Beck, Hans-Peter, Brun, Reto, Nosten, Francois, Renia, Laurent, Dartois, Veronique, Keller, Thomas H., Fidock, David A., Winzeler, Elizabeth A., Diagana, Thierry T.
Publicado em 2010

A broad analysis of resistance development in the malaria parasite

Por Corey, Victoria C., Lukens, Amanda K., Istvan, Eva S., Lee, Marcus C. S., Franco, Virginia, Magistrado, Pamela, Coburn-Flynn, Olivia, Sakata-Kato, Tomoyo, Fuchs, Olivia, Gnädig, Nina F., Goldgof, Greg, Linares, Maria, Gomez-Lorenzo, Maria G., De Cózar, Cristina, Lafuente-Monasterio, Maria Jose, Prats, Sara, Meister, Stephan, Tanaseichuk, Olga, Wree, Melanie, Zhou, Yingyao, Willis, Paul A., Gamo, Francisco-Javier, Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.
Publicado no Nat Commun (2016)

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

Por Kuhen, Kelli L., Chatterjee, Arnab K., Rottmann, Matthias, Gagaring, Kerstin, Borboa, Rachel, Buenviaje, Jennifer, Chen, Zhong, Francek, Carolyn, Wu, Tao, Nagle, Advait, Barnes, S. Whitney, Plouffe, David, Lee, Marcus C. S., Fidock, David A., Graumans, Wouter, van de Vegte-Bolmer, Marga, van Gemert, Geert J., Wirjanata, Grennady, Sebayang, Boni, Marfurt, Jutta, Russell, Bruce, Suwanarusk, Rossarin, Price, Ric N., Nosten, Francois, Tungtaeng, Anchalee, Gettayacamin, Montip, Sattabongkot, Jetsumon, Taylor, Jennifer, Walker, John R., Tully, David, Patra, Kailash P., Flannery, Erika L., Vinetz, Joseph M., Renia, Laurent, Sauerwein, Robert W., Winzeler, Elizabeth A., Glynne, Richard J., Diagana, Thierry T.
Publicado em 2014

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Por Jiménez-Díaz, María Belén, Ebert, Daniel, Salinas, Yandira, Pradhan, Anupam, Lehane, Adele M., Myrand-Lapierre, Marie-Eve, O’Loughlin, Kathleen G., Shackleford, David M., Justino de Almeida, Mariana, Carrillo, Angela K., Clark, Julie A., Dennis, Adelaide S. M., Diep, Jonathon, Deng, Xiaoyan, Duffy, Sandra, Endsley, Aaron N., Fedewa, Greg, Guiguemde, W. Armand, Gómez, María G., Holbrook, Gloria, Horst, Jeremy, Kim, Charles C., Liu, Jian, Lee, Marcus C. S., Matheny, Amy, Martínez, María Santos, Miller, Gregory, Rodríguez-Alejandre, Ane, Sanz, Laura, Sigal, Martina, Spillman, Natalie J., Stein, Philip D., Wang, Zheng, Zhu, Fangyi, Waterson, David, Knapp, Spencer, Shelat, Anang, Avery, Vicky M., Fidock, David A., Gamo, Francisco-Javier, Charman, Susan A., Mirsalis, Jon C., Ma, Hongshen, Ferrer, Santiago, Kirk, Kiaran, Angulo-Barturen, Iñigo, Kyle, Dennis E., DeRisi, Joseph L., Floyd, David M., Guy, R. Kiplin
Publicado no Proc Natl Acad Sci U S A (2014)

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Por Baragaña, Beatriz, Hallyburton, Irene, Lee, Marcus C. S., Norcross, Neil R., Grimaldi, Raffaella, Otto, Thomas D., Proto, William R., Blagborough, Andrew M., Meister, Stephan, Wirjanata, Grennady, Ruecker, Andrea, Upton, Leanna M., Abraham, Tara S., Almeida, Mariana J., Pradhan, Anupam, Porzelle, Achim, Martínez, María Santos, Bolscher, Judith M., Woodland, Andrew, Norval, Suzanne, Zuccotto, Fabio, Thomas, John, Simeons, Frederick, Stojanovski, Laste, Osuna-Cabello, Maria, Brock, Paddy M., Churcher, Tom S., Sala, Katarzyna A., Zakutansky, Sara E., Jiménez-Díaz, María Belén, Sanz, Laura Maria, Riley, Jennifer, Basak, Rajshekhar, Campbell, Michael, Avery, Vicky M., Sauerwein, Robert W, Dechering, Koen J., Noviyanti, Rintis, Campo, Brice, Frearson, Julie A., Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Gamo, Francisco Javier, Wyatt, Paul G., Leroy, Didier, Siegl, Peter, Delves, Michael J., Kyle, Dennis E., Wittlin, Sergio, Marfurt, Jutta, Price, Ric N., Sinden, Robert E., Winzeler, Elizabeth, Charman, Susan A., Bebrevska, Lidiya, Gray, David W., Campbell, Simon, Fairlamb, Alan H., Willis, Paul, Rayner, Julian C., Fidock, David A., Read, Kevin D., Gilbert, Ian H.
Publicado no Nature (2015)