Safety and efficacy of nateglinide/metformin combination therapy in the treatment of type 2 diabetes

Por Israel, Marc K, Istvan, Eva, Baron, Michelle A
Publicado em 2008

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

Por Istvan, Eva S., Palnitkar, Maya, Buchanan, Susan K., Deisenhofer, Johann
Publicado em 2000

Malaria parasite plasmepsins: More than just plain old degradative pepsins

Por Nasamu, Armiyaw S., Polino, Alexander J., Istvan, Eva S., Goldberg, Daniel E.
Publicado no J Biol Chem (2020)

Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems

Por Liu, Jun, Istvan, Eva S., Gluzman, Ilya Y., Gross, Julia, Goldberg, Daniel E.
Publicado em 2006

Antimalarial Activity of Human Immunodeficiency Virus Type 1 Protease Inhibitors

Por Parikh, Sunil, Gut, Jiri, Istvan, Eva, Goldberg, Daniel E., Havlir, Diane V., Rosenthal, Philip J.
Publicado em 2005

Validation of isoleucine utilization targets in Plasmodium falciparum

Por Istvan, Eva S., Dharia, Neekesh V., Bopp, Selina E., Gluzman, Ilya, Winzeler, Elizabeth A., Goldberg, Daniel E.
Publicado em 2011

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

Por Babbitt, Shalon E., Altenhofen, Lindsey, Cobbold, Simon A., Istvan, Eva S., Fennell, Clare, Doerig, Christian, Llinás, Manuel, Goldberg, Daniel E.
Publicado em 2012

Esterase mutation is a mechanism of resistance to antimalarial compounds

Por Istvan, Eva S., Mallari, Jeremy P., Corey, Victoria C., Dharia, Neekesh V., Marshall, Garland R., Winzeler, Elizabeth A., Goldberg, Daniel E.
Publicado no Nat Commun (2017)

Contacting domains segregate a lipid transporter from a solute transporter in the malarial host–parasite interface

Por Garten, Matthias, Beck, Josh R., Roth, Robyn, Tenkova-Heuser, Tatyana, Heuser, John, Istvan, Eva S., Bleck, Christopher K. E., Goldberg, Daniel E., Zimmerberg, Joshua
Publicado no Nat Commun (2020)

Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

Por Istvan, Eva S, Das, Sudipta, Bhatnagar, Suyash, Beck, Josh R, Owen, Edward, Llinas, Manuel, Ganesan, Suresh M, Niles, Jacquin C, Winzeler, Elizabeth, Vaidya, Akhil B, Goldberg, Daniel E
Publicado no eLife (2019)

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery

Por Murithi, James M., Owen, Edward S., Istvan, Eva S., Lee, Marcus C.S., Ottilie, Sabine, Chibale, Kelly, Goldberg, Daniel E., Winzeler, Elizabeth A., Llinás, Manuel, Fidock, David A., Vanaerschot, Manu
Publicado no Cell Chem Biol (2020)

A broad analysis of resistance development in the malaria parasite

Por Corey, Victoria C., Lukens, Amanda K., Istvan, Eva S., Lee, Marcus C. S., Franco, Virginia, Magistrado, Pamela, Coburn-Flynn, Olivia, Sakata-Kato, Tomoyo, Fuchs, Olivia, Gnädig, Nina F., Goldgof, Greg, Linares, Maria, Gomez-Lorenzo, Maria G., De Cózar, Cristina, Lafuente-Monasterio, Maria Jose, Prats, Sara, Meister, Stephan, Tanaseichuk, Olga, Wree, Melanie, Zhou, Yingyao, Willis, Paul A., Gamo, Francisco-Javier, Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.
Publicado no Nat Commun (2016)

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Por Reader, Janette, van der Watt, Mariëtte E., Taylor, Dale, Le Manach, Claire, Mittal, Nimisha, Ottilie, Sabine, Theron, Anjo, Moyo, Phanankosi, Erlank, Erica, Nardini, Luisa, Venter, Nelius, Lauterbach, Sonja, Bezuidenhout, Belinda, Horatscheck, Andre, van Heerden, Ashleigh, Spillman, Natalie J., Cowell, Anne N., Connacher, Jessica, Opperman, Daniel, Orchard, Lindsey M., Llinás, Manuel, Istvan, Eva S., Goldberg, Daniel E., Boyle, Grant A., Calvo, David, Mancama, Dalu, Coetzer, Theresa L., Winzeler, Elizabeth A., Duffy, James, Koekemoer, Lizette L., Basarab, Gregory, Chibale, Kelly, Birkholtz, Lyn-Marié
Publicado no Nat Commun (2021)

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Por Cowell, Annie N., Istvan, Eva S., Lukens, Amanda K., Gomez-Lorenzo, Maria G., Vanaerschot, Manu, Sakata-Kato, Tomoyo, Flannery, Erika L., Magistrado, Pamela, Owen, Edward, Abraham, Matthew, LaMonte, Gregory, Painter, Heather J., Williams, Roy M., Franco, Virginia, Linares, Maria, Arriaga, Ignacio, Bopp, Selina, Corey, Victoria C., Gnädig, Nina F., Coburn-Flynn, Olivia, Reimer, Christin, Gupta, Purva, Murithi, James M., Moura, Pedro A., Fuchs, Olivia, Sasaki, Erika, Kim, Sang W., Teng, Christine H., Wang, Lawrence T., Akidil, Aslı, Adjalley, Sophie, Willis, Paul A., Siege, Dionicio, Tanaseichuk, Olga, Zhong, Yang, Zhou, Yingyao, Llinás, Manuel, Ottilie, Sabine, Gamo, Francisco-Javier, Lee, Marcus C. S., Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.
Publicado no Science (2018)