Plasmodial Kinase Inhibitors: License to Cure?

Autor Cabrera, Diego González, Horatscheck, André, Wilson, Colin R., Basarab, Greg, Eyermann, Charles J., Chibale, Kelly
Vydáno v J Med Chem (2018)

Development of selective inhibitors of phosphatidylinositol 3-kinase C2α

Autor Lo, Wen-Ting, Belabed, Hassane, Kücükdisli, Murat, Metag, Juliane, Roske, Yvette, Prokofeva, Polina, Ohashi, Yohei, Horatscheck, André, Cirillo, Davide, Krauss, Michael, Schmied, Christopher, Neuenschwander, Martin, von Kries, Jens Peter, Médard, Guillaume, Kuster, Bernhard, Perisic, Olga, Williams, Roger L., Daumke, Oliver, Payrastre, Bernard, Severin, Sonia, Nazaré, Marc, Haucke, Volker
Vydáno v Nat Chem Biol (2022)

Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast killing kinetics and in vivo efficacy in the Plasmodium falciparum NSG mouse model

Autor Horatscheck, André, Andrijevic, Ana, Nchinda, Aloysius T., Le Manach, Claire, Paquet, Tanya, Khonde, Lutete Peguy, Dam, Jean, Pawar, Kailash, Taylor, Dale, Lawrence, Nina, Brunschwig, Christel, Gibhard, Liezl, Njoroge, Mathew, Reader, Janette, van der Watt, Mariëtte, Wicht, Kathryn, de Sousa, Ana Carolina C., Okombo, John, Maepa, Keletso, Egan, Timothy J., Birkholtz, Lyn-Marie, Basarab, Gregory S., Wittlin, Sergio, Fish, Paul V., Street, Leslie J., Duffy, James, Chibale, Kelly
Vydáno v J Med Chem (2020)

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Autor Reader, Janette, van der Watt, Mariëtte E., Taylor, Dale, Le Manach, Claire, Mittal, Nimisha, Ottilie, Sabine, Theron, Anjo, Moyo, Phanankosi, Erlank, Erica, Nardini, Luisa, Venter, Nelius, Lauterbach, Sonja, Bezuidenhout, Belinda, Horatscheck, Andre, van Heerden, Ashleigh, Spillman, Natalie J., Cowell, Anne N., Connacher, Jessica, Opperman, Daniel, Orchard, Lindsey M., Llinás, Manuel, Istvan, Eva S., Goldberg, Daniel E., Boyle, Grant A., Calvo, David, Mancama, Dalu, Coetzer, Theresa L., Winzeler, Elizabeth A., Duffy, James, Koekemoer, Lizette L., Basarab, Gregory, Chibale, Kelly, Birkholtz, Lyn-Marié
Vydáno v Nat Commun (2021)