Development of selective inhibitors of phosphatidylinositol 3-kinase C2α

Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis, and platelet morphology and function. Herein we report the development an...

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Udgivet i:Nat Chem Biol
Main Authors: Lo, Wen-Ting, Belabed, Hassane, Kücükdisli, Murat, Metag, Juliane, Roske, Yvette, Prokofeva, Polina, Ohashi, Yohei, Horatscheck, André, Cirillo, Davide, Krauss, Michael, Schmied, Christopher, Neuenschwander, Martin, von Kries, Jens Peter, Médard, Guillaume, Kuster, Bernhard, Perisic, Olga, Williams, Roger L., Daumke, Oliver, Payrastre, Bernard, Severin, Sonia, Nazaré, Marc, Haucke, Volker
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group US 2022
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613998/
https://ncbi.nlm.nih.gov/pubmed/36109648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-022-01118-z
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