Development of selective inhibitors of phosphatidylinositol 3-kinase C2α

Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis, and platelet morphology and function. Herein we report the development an...

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Publicado no:Nat Chem Biol
Main Authors: Lo, Wen-Ting, Belabed, Hassane, Kücükdisli, Murat, Metag, Juliane, Roske, Yvette, Prokofeva, Polina, Ohashi, Yohei, Horatscheck, André, Cirillo, Davide, Krauss, Michael, Schmied, Christopher, Neuenschwander, Martin, von Kries, Jens Peter, Médard, Guillaume, Kuster, Bernhard, Perisic, Olga, Williams, Roger L., Daumke, Oliver, Payrastre, Bernard, Severin, Sonia, Nazaré, Marc, Haucke, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group US 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613998/
https://ncbi.nlm.nih.gov/pubmed/36109648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-022-01118-z
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