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Validation of isoleucine utilization targets in Plasmodium falciparum

Intraerythrocytic malaria parasites can obtain nearly their entire amino acid requirement by degrading host cell hemoglobin. The sole exception is isoleucine, which is not present in adult human hemoglobin and must be obtained exogenously. We evaluated two compounds for their potential to interfere...

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Detalhes bibliográficos
Main Authors: Istvan, Eva S., Dharia, Neekesh V., Bopp, Selina E., Gluzman, Ilya, Winzeler, Elizabeth A., Goldberg, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029723/
https://ncbi.nlm.nih.gov/pubmed/21205898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011560108
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