Spiroindolones, a new and potent chemotype for the treatment of malaria

Recent reports of increased tolerance to artemisinin derivatives—the last widely effective class of antimalarials — bolster the medical need for new treatments. The spirotetrahydro-β–carbolines, or spiroindolones, are a new class of fast-acting and potent schizonticidal drugs displaying low nanomola...

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Hlavní autoři: Rottmann, Matthias, McNamara, Case, Yeung, Bryan K. S., Lee, Marcus C. S., Zou, Bin, Russell, Bruce, Seitz, Patrick, Plouffe, David M., Dharia, Neekesh V., Tan, Jocelyn, Cohen, Steven B., Spencer, Kathryn R., González-Páez, Gonzalo E., Lakshminarayana, Suresh B., Goh, Anne, Suwanarusk, Rossarin, Jegla, Tim, Schmitt, Esther K., Beck, Hans-Peter, Brun, Reto, Nosten, Francois, Renia, Laurent, Dartois, Veronique, Keller, Thomas H., Fidock, David A., Winzeler, Elizabeth A., Diagana, Thierry T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050001/
https://ncbi.nlm.nih.gov/pubmed/20813948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1193225
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