A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609

Recent clinical trials revealed a surprisingly rapid clearance of red blood cells (RBCs) infected with malaria parasites by the spiroindolone KAE609. Here, we show that ring-stage parasite–infected RBCs exposed to KAE609 become spherical and rigid, probably through osmotic dysregulation consequent t...

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Foilsithe in:J Infect Dis
Main Authors: Zhang, Rou, Suwanarusk, Rossarin, Malleret, Benoit, Cooke, Brian M., Nosten, Francois, Lau, Yee-Ling, Dao, Ming, Lim, Chwee Teck, Renia, Laurent, Tan, Kevin Shyong Wei, Russell, Bruce
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2016
Ábhair:
Major Articles and Brief Reports
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4676544/
https://ncbi.nlm.nih.gov/pubmed/26136472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv358
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