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The Spiroindolone KAE609 Does Not Induce Dormant Ring Stages in Plasmodium falciparum Parasites

In vitro drug treatment with artemisinin derivatives, such as dihydroartemisinin (DHA), results in a temporary growth arrest (i.e., dormancy) at an early ring stage in Plasmodium falciparum. This response has been proposed to play a role in the recrudescence of P. falciparum infections following mon...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Chavchich, Marina, Van Breda, Karin, Rowcliffe, Kerryn, Diagana, Thierry T., Edstein, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997877/
https://ncbi.nlm.nih.gov/pubmed/27297484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02838-15
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