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Spiroindolone KAE609 for Falciparum and Vivax Malaria

BACKGROUND: KAE609 (cipargamin; formerly NITD609, Novartis Institute for Tropical Diseases) is a new synthetic antimalarial spiroindolone analogue with potent, dose-dependent antimalarial activity against asexual and sexual stages of Plasmodium falciparum. METHODS: We conducted a phase 2, open-label...

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Détails bibliographiques
Auteurs principaux: White, Nicholas J., Pukrittayakamee, Sasithon, Phyo, Aung Pyae, Rueangweerayut, Ronnatrai, Nosten, François, Jittamala, Podjanee, Jeeyapant, Atthanee, Jain, Jay Prakash, Lefèvre, Gilbert, Li, Ruobing, Magnusson, Baldur, Diagana, Thierry T., Leong, F. Joel
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143746/
https://ncbi.nlm.nih.gov/pubmed/25075833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1315860
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