Na(+) Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials

The malaria parasite Plasmodium falciparum establishes in the host erythrocyte plasma membrane new permeability pathways that mediate nutrient uptake into the infected cell. These pathways simultaneously allow Na(+) influx, causing [Na(+)] in the infected erythrocyte cytosol to increase to high leve...

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Main Authors: Spillman, Natalie J., Allen, Richard J.W., McNamara, Case W., Yeung, Bryan K.S., Winzeler, Elizabeth A., Diagana, Thierry T., Kirk, Kiaran
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574224/
https://ncbi.nlm.nih.gov/pubmed/23414762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.12.006
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